Pathogenesis of SARS coronavirus infection using human lung epithelial cells: an in vitro model.
نویسندگان
چکیده
1. In vitro models of welldifferentiated bronchial epithelial cells and alveolar type II and type I–like pneumocytes were set up. 2. The SARS-CoV could replicate in well-differentiated bronchial epithelial cells and alveolar type II pneumocytes only. 3. In well-differentiated bronchial epithelial cells, type I interferons (interferon-beta) and cytokine and chemokines (eg RANTES, IP-10, IL-6, IL8, MCP-1, MIP-1α, MIP-2α) were markedly induced after infection with SARS-CoV, compared to human coronavirus HCoV229E and influenza A (H1N1) virus.
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عنوان ژورنال:
- Hong Kong medical journal = Xianggang yi xue za zhi
دوره 17 Suppl 6 شماره
صفحات -
تاریخ انتشار 2011